Atypical presentation of Sézary Syndrome with CD4+/CD7+/CD26- T-cells and marked epidermotropism: A case report and literature review
نویسنده
چکیده
Figure 3. Scalp with prominent epidermal and follicular involvement by atypical lymphocytes (50x). Abstract We present an atypical case of Sézary syndrome in a 46-year-old African American female who presented with tenderness, pruritus, hyperpigmented lesions and lymphadenopathy. Her condition was characterized by the retention of T-cell CD7 expression, significant atypical lymphocytic epidermotropism that histologically mimicked mycosis fungoides, and circulating Sézary cells ( CD4+/CD7+/CD26-) of fewer than 1000/uL. It is important to recognize this unique presentation and be able to differentiate it from mycosis fungoides (MF), as this can significantly alter the prognosis and treatment while having an impact on the patient’s life.
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